Post by account_disabled on Oct 26, 2023 8:22:46 GMT 1
The present study evaluated whether the administration of melatonin during adolescence can prevent the harmful effects produced by alcohol on the liver. Thirty albino rats ( Rattus norvegicus albinus ), females, 40 days old, virgin, weighing approximately 150±10g, of the Wistar lineage, were divided into the following groups: I – Adolescent rats that did not receive alcohol and were sacrificed at 60 days of age. life; II – Adolescent rats subjected to chronic alcohol consumption and sacrificed at 60 days of age; III – Adolescent rats subjected to chronic alcohol consumption and simultaneously treated with melatonin, and sacrificed at 60 days of life.
The collected organs underwent histological processing and, to obtain the results, morphometric, histopathological and histochemical analyzes were carried out. Alcohol was administered by gavage, via intragastric injection, at a dose of 3 g/kg of ethyl alcohol to rats in groups II and III, for 20 days. Melatonin was administered in daily injections of 0.8 mg/kg, always at the beginning of the night, intraperitoneally, for 20 days. When analyzing the weight of the animals, no significant difference was observed between the groups. The europe mobile number list animals in group II presented changes in the livers, such as congestion of the centrilobular vein, hepatocellular ballooning, microgoticular steatosis, leukocyte infiltrate, several pyknotic nuclei in the livers, increase in the lobular parenchyma and reduction in the non-lobular parenchyma, greater collagen deposition and reduction of glycogen. . Melatonin treatment prevented all of these changes. With this, we can conclude that melatonin has great therapeutic potential in preventing liver damage in adolescent rats subjected to moderate alcohol consumption, in addition to positive effects on the deposition of collagen and glycogen in the liver.
Keywords: Adolescents, Alcohol, Antioxidant, Liver, Inflammation. 1. INTRODUCTION The consumption of alcoholic beverages is common throughout the world, and factors such as age, culture, gender and religion influence both the frequency and volume consumed. Around 43% of the global population consumes alcoholic beverages, and in the Americas region, this rate is higher than the global average, reaching 54% (WHO, 2018). In Brazil, approximately 25 million inhabitants, which is equivalent to 16.5% of the population, consumed more alcohol in 2015 (FIOCRUZ, 2017).
The collected organs underwent histological processing and, to obtain the results, morphometric, histopathological and histochemical analyzes were carried out. Alcohol was administered by gavage, via intragastric injection, at a dose of 3 g/kg of ethyl alcohol to rats in groups II and III, for 20 days. Melatonin was administered in daily injections of 0.8 mg/kg, always at the beginning of the night, intraperitoneally, for 20 days. When analyzing the weight of the animals, no significant difference was observed between the groups. The europe mobile number list animals in group II presented changes in the livers, such as congestion of the centrilobular vein, hepatocellular ballooning, microgoticular steatosis, leukocyte infiltrate, several pyknotic nuclei in the livers, increase in the lobular parenchyma and reduction in the non-lobular parenchyma, greater collagen deposition and reduction of glycogen. . Melatonin treatment prevented all of these changes. With this, we can conclude that melatonin has great therapeutic potential in preventing liver damage in adolescent rats subjected to moderate alcohol consumption, in addition to positive effects on the deposition of collagen and glycogen in the liver.
Keywords: Adolescents, Alcohol, Antioxidant, Liver, Inflammation. 1. INTRODUCTION The consumption of alcoholic beverages is common throughout the world, and factors such as age, culture, gender and religion influence both the frequency and volume consumed. Around 43% of the global population consumes alcoholic beverages, and in the Americas region, this rate is higher than the global average, reaching 54% (WHO, 2018). In Brazil, approximately 25 million inhabitants, which is equivalent to 16.5% of the population, consumed more alcohol in 2015 (FIOCRUZ, 2017).